白癜风专科医院哪家好 https://baike.baidu.com/item/%E5%8C%97%E4%BA%AC%E4%B8%AD%E7%A7%91%E7%99%BD%E7%99%9C%E9%A3%8E%E5%8C%BB%E9%99%A2/9728824?fr=aladdinCardio‐microcurrentdeviceforchronicheartfailure
irst‐in‐humanclinicalstudyESCHeartFailureArticleEarlyRecent,Feb09,./ehf2.本文由“天纳”临床学术信息人工智能系统自动翻译点击文末“阅读原文”下载本文PDFAimsMostdevicesfortreatingambulatoryClassIIandIIIheartfailurearelinkedtoelectricalpulses.However,asteadyelectricpotentialgradientisalsonecessaryforappropriatemyocardialperformanceandmaybedisturbedbystructuralheartdiseases.Weinvestigatedwhetherchronicapplicationofelectricalmicrocurrenttotheheartisfeasibleandsafeandimprovescardiacperformance.Theresultsofthisstudyshouldprovideguidanceforthedesignofatwo‐arm,randomized,controlledPhaseIItrial.大多数治疗非卧床II级和III级心力衰竭的设备都与电脉冲有关。然而，稳定的电位梯度对于适当的心肌功能也是必要的，并且可能受到结构性心脏病的干扰。我们研究了在心脏长期应用微电流是否可行和安全，是否能改善心脏功能。这项研究的结果应该为两臂随机对照II期试验的设计提供指导。MethodsandresultsThissingle‐arm,non‐randomizedpilotstudyinvolved10patients(9men;meanage,62?±?12?years)attwositeswith6?monthfollow‐up.AllpatientshadNewYorkHeartAssociation(NYHA)ClassIIIheartfailureandnon‐ischaemicdilatedcardiomyopathy,withleftventricularejectionfraction(LVEF)35%.Adevicewassurgicallyplacedtodeliveraconstantmicrocurrenttotheheart.Thefollowingtestswereperformedatbaseline,athospitaldischarge,andatsixtimepointsduringfollow‐up
eterminationofLVEFandleftventricularend‐diastolic/end‐systolicdiameterbyechocardiography;the6?minwalktest;andassessmentofNYHAclassificationandqualityoflife(36‐ItemShort‐FormHealthSurveyquestionnaire).Microcurrentapplicationwasfeasibleandsafe;nodevice‐relatedortreatment‐relatedadverseeventsoccurred.Duringfollow‐up,rapidandsignificantsignalofefficacy(P??0.)waspresentwithimprovementsinLVEF,leftventricularend‐diastolicdiameter,leftventricularend‐systolicdiameter,anddistancewalked.Foreightpatients,NYHAclassificationimprovedfromClassIIItoClassI(forseven,asearlyas14?dayspost‐operatively);forone,toClassII;andforone,toClassII/III.36‐ItemShort‐FormHealthSurveyquestionnairescoresalsoimprovedhighlysignificantly.这项单臂、非随机的试点研究涉及两个地点的10名患者（9名男性，平均年龄62±12岁），随访6个月。所有患者均患有纽约心脏病协会（NYHA）III级心力衰竭和非缺血性扩张型心肌病，左室射血分数（LVEF）<；35%。手术中放置了一个装置，向心脏输送恒定的微电流。在基线检查时、出院时和随访期间的6个时间点进行以下测试：通过超声心动图测定LVEF和左室舒张末/收缩末内径；6分钟步行测试；NYHA分类和生活质量评估（36项简式健康调查问卷）。微电流应用是可行和安全的；没有发生与设备或治疗相关的不良事件。在随访期间，随着左室射血分数、左室舒张末期内径、左室收缩末期内径和步行距离的改善，出现了快速而显著的疗效信号（P0.）。对于8名患者，NYHA分类从III级提高到I级（7名患者，最早在术后14天）；1名患者提高到II级；1名患者提高到II/III级。36项简式健康调查问卷得分也显著提高。ConclusionsChronicapplicationofmicrocurrenttotheheartisfeasibleandsafeandleadstoarapidandlastingimprovementinheartfunctionandanearnormalizationofheartsizewithindays.TheNYHAclassificationandqualityoflifeimprovejustasrapidly.慢性应用微电流到心脏是可行和安全的，并导致快速和持久的心脏功能改善和心脏大小在几天内接近正常化。NYHA的分类和生活质量也得到了同样迅速的改善。IntroductionTherapyforheartfailureisappliedinastepwisegraduatedmanner.1,2If,despiteoptimalpharmacologicaltherapy,cardiacfunctioncontinuestodecline,treatmentwithdevicesmustbeconsidered.3,4However,devicesforcardiacresynchronizationtherapy(CRT)orcardiaccontractilitymodulationcanbeconsideredforonlyaminorityofpatientsduetorestrictionsthathaveemergedinclinicalstudies(QRS
